Gallery: Red fightback
It looked like it was going to be a day to forget on the South Coast for the United, but Robin van Persie, eventually, ensured it was one to remember for Sir Alex Ferguson in his 1000th league game in charge.
Southampton put up a brave fight throughout the 90 minutes and took the lead twice. But we all know the Reds never give up and we had van Persie to thank, twice, for drawing us level. He may have missed a penalty between the two equalisers, but all was forgiven as the game went into injury time and the Dutchman headed home a brilliant winner to complete his first hat-trick for the club on only his third appearance.